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      目前國內哪里購買買得到勞拉替尼3922?薇bxyzxq 什么價格?多少錢一個月

    1. 采購類型:現貨/標準
    2. 詢價日期:2019-06-08
    3. 聯系方式: 報價后可見
    4. 分享到:
      本公司長期代購:易瑞沙/吉非替尼   特羅凱/厄洛替尼  azd9291 原料   吉三代    克唑替尼/賽可瑞  ap26113 卡博替尼/xl184  阿法替尼/2992    wz4002 adz3759  299804/達克替尼  多吉美/索拉美尼  格列衛/伊馬替尼  司美替尼/6244  色瑞替尼/ldk378    奧拉帕尼  勞拉替尼3922   azd9291(孟白盒)  azd9291(孟黑盒)價格、多少錢、功效、作用、效果、副作用、
      EGFR基因90%以上的突變發生在19號外顯子缺失和21號外顯子的L858R。這兩種突變位點適用于第一代EGFR靶向物吉非替尼、厄洛替尼、埃克替尼。19外顯子缺失和L858R突變之外的稱之為罕見突變,如L861Q,G719X,S768I等,這些突變位點適合使用第二代靶向物阿法替尼,即不可逆的EGFR和HER2雙重抑制劑。雖然有臨床研究表明,阿法替尼相比吉非替尼可改善PFS和客觀響應率,但是副作用較大,目前阿法替尼優勢還是在EGFR的罕見突變位點,或Her2突變導致的耐。

      存在腦轉移的EGFR患者,現有的研究表明如果可以使用靶向物控制就不進行放療,全腦放療僅有一次機會。如果病灶數目小且不超過3個,不能靶向控制,就使用伽馬刀。入腦效果較好的靶向物有特羅凱,達克替尼(PF299804)、AZD3759,AZD9291等。癌度提醒您,需注意的是臨床階段的AZD3759不具有T790M靶點,存在T790M突變的腦轉患者建議選擇AZD9291。

      ALK融合基因發現于2007年,后續一系列對應的靶向物相繼出現,目前ALK的靶向物也有3代了。*常見于ALK基因的20號外顯子與EML4發生融合,其他的融合伴侶基因還有KIF5B、TFG和KLC1等,目前發現有27種融合形式,因此檢測時需確保這些融合位點都做了詳細的覆蓋,避免漏檢。ALK在非小細胞肺癌

      ALK突變的第一代靶向物是克唑替尼,2011年獲批上市,克唑替尼具有ALK、ROS1和C-MET三個靶點。存在ALK突變的患者使用克唑替尼的中位PFS約為9.7個月。克唑替尼耐后可以使用第二代ALK抑制劑,主要有色瑞替尼(LDK378)、艾樂替尼(CH5424802)、Brigatinib(AP26113)和X-396,其中色瑞替尼和艾樂替尼已經獲批上市。

      ALK的第三代靶向物是PF-06463922,該幾乎可以抑制導致克唑替尼耐的所有耐位點,靶向ALK和ROS1。*新的研究發現ALK的L1198F突變也導致PF-06463922耐,但是這一耐位點可以重新用回第一代克唑替尼。


      3、ROS1基因

      中的突變頻率為1-2%,多見于肺腺癌,目前鑒定出9種融合突變形式。ROS1基因檢測的金標準是FISH,其他檢測技術有免疫組化、二代測序等。存在ROS1突變的患者一般較為年輕。

      4、RET融合

      的突變頻率為1-2%,非吸煙的肺腺癌和鱗癌里都可能存在RET基因融合突變。RET基因的檢測技術與ALK和ROS1的一樣,都是FISH、免疫組化和測序等。

      5、c-MET擴增或14外顯子跳躍突變

      另外*近發現的c-MET基因的14號外顯子跳躍式突變也是一個驅動突變,14外顯子跳躍式突變在肺腺癌的頻率為3-4%,患者使用克唑替尼或卡博替尼也可以獲益。

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      公司詳情

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      • 主營行業:文具
      • 注冊資本:人民幣 10 萬元以下
      • 創建時間:2011-01-17

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