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      提高抗癌靶向藥物克唑替尼賽可瑞多少錢?購買渠道途徑咨詢V商bxyzxq

    1. 采購類型:現貨/標準
    2. 詢價日期:2019-06-08
    3. 聯系方式: 報價后可見
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      咨詢電話:17161077085微信:bxyzxq     艾女士11月21日,美國食品藥品管理局(FDA)聲明宣布,鑒于最新研究表明克唑替尼治療患者的無進展生存期和總應答率均優于化療患者,已完全批準激酶抑制劑克唑替尼(crizotinib)用于轉移性非小細胞肺癌(NSCLC)的治療。

      2011年8月,FDA在批準間變性淋巴瘤激酶(ALK)檢測方法的同時,加速批準了克唑替尼用于該檢測方法確認的ALK陽性NSCLC的治療。這是基于在2項單臂開放性試驗中,客觀應答率分別為50%和61%。而這次完全批準令則是依據新的證據進一步確認了上述臨床獲益。

      新證據來自一項國際多中心開放性隨機研究。該研究納入了347例接受了以鉑為基礎的化療后出現進展的ALK陽性轉移性NSCLC患者。這些患者隨機接受克唑替尼治療或化療,如果化療患者此前已接受了培美曲塞治療,則繼續接受培美曲塞或多西他賽治療。

      克唑替尼組和化療組中位無進展生存期分別為7.7個月和3.0個月,前者風險下降51%[風險比(HR)為0.49] ,差異顯著。客觀應答率分別為65%和20%,差異也呈顯著。中位應答時間分別為7.4個月和5.6個月。不過按照計劃進行的中期分析顯示,兩組總生存率相似。

      與克唑替尼治療相關的常見不良事件包括惡心、腹瀉、嘔吐、視覺障礙、便秘、水腫、轉氨酶升高和疲乏,累及至少25%的治療患者。

      對172例克唑替尼治療患者的安全性評價分析顯示,37%的患者出現嚴重不良事件,最常見的包括肺炎、肺栓塞、呼吸困難和間質性肺病。不良事件導致9例患者死亡,包括急性呼吸窘迫綜合征、心律失常、呼吸困難、肺炎、吸入性肺炎、肺栓塞、間質性肺炎、呼吸衰竭以及膿毒癥。

      克唑替尼將由輝瑞制藥以Xalkori商品名上市,為膠囊劑型,250 mg/次,2次/日,單獨或與食物同服。

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